My long-term research interests are to better understand how the brain recovers and reorganizes in those with acquired neurogenic communication impairments, such as aphasia, as well as how recovery can be facilitated using techniques like non-invasive brain stimulation (NIBS) to achieve improved rehabilitation outcomes. I am especially interested in exploring how the neural correlates of recovery and reorganization may differ depending on lesion location and severity as well as identifying optimal behavioral therapies to administer in conjunction with NIBS, to best facilitate neuroplasticity.
Neural Compensation in the Language Network (NIH NCATS TL1TR002735 Training grant awarded to Victoria Diedrichs with mentorship from Dr. Stacy Harnish, Dr. David Osher, and Prof. Jennifer Brello)
Aphasia impacts approximately one-third of stroke survivors as a result of damage to the language network in the brain. After only a few months, recovery begins to plateau, leading to less than a quarter of individuals with aphasia making a full recovery by 18 months post-stroke. Rehabilitation can continue to facilitate improvements in these individuals with chronic aphasia; however, progress is slow, despite continued use of evidence-based therapeutic interventions by trained speech-language pathologists. Crucially, little is known about the compensatory mechanisms that take place at the neurological level among individuals recovering from aphasia, which could be promoted using technology such as non-invasive brain stimulation to improve recovery. Motivated by a lack of clarity surrounding cortical compensation within the language network, this study aims to use resting state functional connectivity neuroimaging and a series of semantic and phonological working memory tasks to explore compensatory activity further. Sites such as the anterior superior temporal gyrus and posterior middle temporal gyrus have been implicated by previous findings to compensate for language processing in individuals with lesions to the inferior frontal gyrus. Our findings will have broad implications for our understanding of neuroplasticity within the language network of individuals with aphasia and more specifically inform montage placement for future clinical trials of non-invasive brain stimulation techniques.
Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response (NIH NIDCD R01DC017711, PI: Dr. Stacy Harnish)
This NIH-funded project is investigating patient-specific factors that may influence response to therapy for language impairment after stroke, or aphasia. Results from this work will assist with better estimation of prognosis for stroke survivors with aphasia, which could empower patients and families to make more informed health care decisions about how to pursue the most appropriate rehabilitation services based on their unique characteristics, such as genetics, cognitive skills, and brain structure after stroke. Dr. Stacy Harnish (Associate Professor in Speech and Hearing Science) with co-investigators Christopher Bartlett (Nationwide Children’s Hospital), Jeff Pan (Biomedical Informatics), Stephen Petrill (Psychology), David Osher (Psychology), and Vivien Lee (Neurology) were awarded a five-year, $2.3 million grant from the National Institute on Deafness and other Communication Disorders to complete this work. My role in this project has been to manage staff and student training, recruitment, and data collection.